Abstract

Background: There are limited data regarding the antifungal susceptibility of Candida albicans causing recurrent vulvovaginal candidiasis.

 

Objective: The aim of the present study was to evaluate the effect of azoles susceptibilities on treatment failure and recurrence of vulvovaginal candidiasis.

Methods: Species identification was performed on 84 vaginal Candida isolates collected from October 2008 to June 2010 from 404 patients with suspected vulvovaginitis. MICs of C. albicans (26 isolates) to fluconazole, itraconazole, and voriconazole were tested by broth microdilution method of the Clinical and Laboratory Standards Institute (CLSI)

M27-A2.

Results: C. albicans was the most frequently isolated (88.1%). All isolates were susceptible to fluconazole, itraconazole, and voriconazole. Trailing growth was found in treatment success group (10.0%) and treatment failure group (33.3%).

Conclusions: The results of this study suggest the possibility that trailing growth have influence on treatment failure of vulvovaginal candidiasis.

Keywords

Recurrent vulvovaginal candidiasis Candida albicans Azole susceptibility

KJMM 2011 March;16(1):24-30(7). Epub 2016 February 18
Copyright © 2011 by Korean Journal of Medical Mycology

Language

Korean/English

Author

Kye Hyun Kim; Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
Tae-Hyoung Kim; Departments of Urology, Chung-Ang University College of Medicine, Seoul, Korea
Mi-Kyung Lee; Departments of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea

Corresponding

Mi-Kyung Lee, Departments of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea. Tel: (02) 6299-2719, Fax: (02) 6298-8630, e-mail: cpworld@cau.ac.kr

Publication history

Received 5 March 2011; Revised 18 March 2011; Accepted 23 March 2011.

Acknowledgements

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Kye Hyun Kim

Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

Tae-Hyoung Kim

Departments of Urology, Chung-Ang University College of Medicine, Seoul, Korea

Mi-Kyung Lee

Departments of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea

Since epub date 2016 February 18