pISSN : 1226-4709 eISSN: 2465-8278
Open Access, Peer-reviewed
pISSN : 1226-4709 eISSN: 2465-8278
Open Access, Peer-reviewed
Young Ji Hwang,Yang Won Lee,Yong Beom Choe,Kyu Joong Ahn
Epub 2016 February 18
Abstract
Background: Luliconazole (LLCZ) is an imidazole antifungal agent widely used in Japan for treatment of tinea, cutaneous candidiasis, and pityriaisis versicolor, etc. Theoretically, its potent antifungal activity should make it a viable option for various conditions of dermatophytoses, but there has been no studies to support the notion thus far.
Objective: This prompted the authors to investigate the distribution of minimum inhibitory concentration (MIC) of luliconazole by carrying out in vitro antifungal susceptibility test on Trichophyton (T.) species clinically isolated from Korean subjects with tinea pedis.
Methods: In vitro antifungal susceptibility test, with broth macrodilution method of luliconazole and terbinafine hydrochloride (TBF) as reference drug on two clinically isolated Trichophton species (22 strains of T. rubrum, 5 of T. mentagrophytes), was carried out.
Results: The range of MIC for LLCZ on the total of 27 strains was 0.0110~0.0140 μg/mL (geometric mean: 0.0027 μg/mL), and the range for TBF was 0.0120~0.0250 μg/mL (geometric mean: 0.0042 μg/mL). Additionally, the geometric mean for MIC of LLCZ on T. mentagrophytes was 0.0125 μg/mL, and on T. rubrum, it was 0.0019 μg/mL.
No strain showed resistance in vitro.
Conclusions: The authors hence demonstrated that antifungal activity of LLCZ in vitro against Trichophyton species clinically isolated from Korean subjects is quite superior. These findings emphasize the usefulness of LLCZ, a promising new imidazole, for the topical management of dermatophytoses.
Keywords
Luliconazole Trichophyton Minimum inhibitory concentration
