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A Study of Potential Application of Rubus coreanus Miquel Extract for Seborrheic Dermatitis Treatment

Yun Young Lim,Woo Sun Jang,Hyeong Mi Kim,Min Young Kim,Sang Ah Oh,Jin Oh Park,Youn Tae Kim,Jong Ho Park,Young Jin Chun,Ji Won Li,Kwon Ki Moon,Beom Joon Kim,Myeung Nam Kim,Young Min Park,Hoon Kang
Epub 2016 February 18

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Abstract



Background: Seborrheic dermatitis is chronic relapsing inflammatory skin disorder. Bokbunja (Rubus coreanus Miquel) is a wild berry to Rosaceae genus and also known to have an anti-inflammation effect.


Objective: We were to determine the effect of Rubus coreanus Miquel extract for seborrheic dermatitis in vivo and in vitro.


Methods: Seven patients with mild seborrheic dermatitis were enrolled in this study. PCR and culture were performed to identify subtypes of six Malassezia species (M. restricta, M. globosa, M. furfur, M. slooffiae, M. sympodialis, M. obtusa). Topical application of Rubus coreanus Miquel Extract was applied twice daily for 2 weeks. Clinical improvement and safety assessment were performed initially and 2 weeks later. Minimum inhibitory concentration (MIC) was evaluated on Malassezia globosa comparing with ketoconazole and itraconazole. Sebum production was also checked prior the experiment and 2 weeks later.


Results: Five of seven patients showed improvement. No significant adverse effects were found during the clinical trial. Mild dryness was reported in 2 patients but they resolved spontaneously without any treatment. Rubus coreanus Miquel Extract didn't show antimicrobial effect to Malassezia globosa. However, Rubus coreanus Miquel Extract showed anti-inflammatory effect.


Conclusion: In this study, we were verified that Rubus coreanus Miquel Extract can be applied for seborrheic dermatitis treatment. And this action mechanism is not related with antimicrobial effect.



Keywords


Malassezia Seborrheic dermatitis Rubus coreanus Miquel




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