Abstract

Scedosporium apiospermum is a rising opportunistic fungus that may infect immunocompetent individuals and may cause often fatal disease among the increasing immunosuppressed patient population. This pathogen is typically difficult to treat because of its particular resistance to commonly used antimycotic drugs. We describe an 83-year-old male patient with a history of long-term corticosteroid treatment for chronic prurigo simplex, who developed multiple suppurative nodules on a erythematous plaque at the right forearm. Histological examinations revealed granulomatous infiltration with hyphae and spores in dermis and fungal cultured isolation for definitive diagnosis showed S. apiospermum. Treatment was started with oral fluconazole, but skin lesions were getting worse. Then patient was

treated with 200 mg of intravenouse itraconazole daily. Skin lesions showed a marked improvement after 1 week, and completely healing after 3 weeks.

Keywords

Itraconazole Scedosporium apiospermum

KJMM 2011 September;16(3):105-108(4). Epub 2016 February 17
Copyright © 2011 by Korean Journal of Medical Mycology

Language

Korean/English

Author

Sooyeon Kim; Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea
Sangshin Lee; Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea
Young Lee; Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea
Youngjoon Seo; Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea
Jeunghoon Lee; Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea
Myung Im; Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea

Corresponding

Myung Im, Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea. Tel: (042) 280-7704, Fax: (042) 280-8877, e-mail: im1177@hanmail.net

Publication history

Received 31 March 2011; Revised 6 April 2011; Accepted 7 April 2011.

Acknowledgements

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Sooyeon Kim

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea

Sangshin Lee

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea

Young Lee

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea

Youngjoon Seo

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea

Jeunghoon Lee

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea

Myung Im

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea

Since epub date 2016 February 17