Abstract

Cutaneous manifestation due to Cryptococcus neoformans is mostly reported in cases of the secondary findings to hematogenous dissemination while the primary cutaneous cryptococcosis (PCC) is a very rare. PCC usually occurs in immunocompromised hosts such as AIDS, hematopoietic malignancies, transplant recipients, and chronic corticosteroid users. Primary cryptococcosis and tuberculosis co-infection has been rarely reported in Korean literature. We report a case of PCC in a 22-year-old male with pulmonary tuberculosis, who had asymptomatic erythematous plaque and papules on the right cheek for 3 months. Histopathological examination showed numerous encapsulated round spores in the dermis and the organism was identified as Cryptococcus neoformans on fungal culture. The lesion was successfully treated with oral fluconazole for 6 months, and pulmonary tuberculosis was resolved after anti-tuberculosis

therapy for 9 months.

Keywords

Primary cutaneous cryptococcosis Pulmonary tuberculosis Co-infection

KJMM 2013 December;18(4):111-116(6). Epub 2016 February 17
Copyright © 2013 by Korean Journal of Medical Mycology

Language

Korean/English

Author

Tae Wook Kim; Department of Dermatology, School of Medicine, Pusan National University
Sung Min Park; Department of Dermatology, School of Medicine, Pusan National University; Pusan National University Yangsan Hospital; Dermatology
Je Ho Moon; Department of Dermatology, School of Medicine, Pusan National University; Pusan National University Yangsan Hospital; Dermatology
Margaret Song; Department of Dermatology, School of Medicine, Pusan National University
Hoon Soo Kim; Department of Dermatology, School of Medicine, Pusan National University
Byung Soo Kim; Department of Dermatology, School of Medicine, Pusan National University
Moon Bum Kim; Department of Dermatology, School of Medicine, Pusan National University
Hyun Chang Ko; Department of Dermatology, School of Medicine, Pusan National University; Pusan National University Yangsan Hospital; Dermatology

Corresponding

Hyun Chang Ko, Pusan National University Yangsan Hospital; Dermatology. Tel: +82-55-360-1678, Fax: +82-55-360-1679, e-mail: hcko@pusan.ac.kr

Publication history

Received 23 December 2013; Revised 24 December 2013; Accepted 2 January 2014.

Acknowledgements

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Tae Wook Kim

Department of Dermatology, School of Medicine, Pusan National University

Sung Min Park

Department of Dermatology, School of Medicine, Pusan National University; Pusan National University Yangsan Hospital; Dermatology

Je Ho Moon

Department of Dermatology, School of Medicine, Pusan National University; Pusan National University Yangsan Hospital; Dermatology

Margaret Song

Department of Dermatology, School of Medicine, Pusan National University

Hoon Soo Kim

Department of Dermatology, School of Medicine, Pusan National University

Byung Soo Kim

Department of Dermatology, School of Medicine, Pusan National University

Moon Bum Kim

Department of Dermatology, School of Medicine, Pusan National University

Hyun Chang Ko

Department of Dermatology, School of Medicine, Pusan National University; Pusan National University Yangsan Hospital; Dermatology

Since epub date 2016 February 17