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Antifungal Effect of Jungrowhan® and Vinegar to Fungi Causing Skin Infection

Young Mook Yoon,Sang Won Kim,Dong Seok Kim
Epub 2016 February 24

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Abstract



BACKGROUND: Even though recent improvement of antifungal agent is remarkable, side effect makes patient hesitate to use them. Instead, mixture of Jungrowhan® and vinegar is traditionally used and it makes contact dermatitis and secondary bacterial infection.


OBJECTIVE: We tested antifungal activity of vinegar and Jungrowhan® to know their its efficacy.


METHOD: Candida albicans (CA), Trichophyton rubrum (TR), Trichophyton mentagrophytes (TM) were cultivated in Sabouraud dextrose agar admixed with various amounts of Jungrowhan® and vinegar. We used the standard checkerboard titration for detecting synergy or antagonism of these two materials. Using the individual ingredients of Jungrowhan®, sensitivity tests were done.


RESULTS: Minimum inhibitory concentrations (MICs) of Jungrowhan®, were 6~8 mg/ml in CA, 2 mg/ml in TR and 2~4 mg/ml in TM. MICs of vinegar were 0.05~0.2 ml/ml in CA, 0.02~0.03 ml/ml in TR and 0.01~0.02 ml/ml in TM. The checkerboard titration of two materials revealed no synergism. MIC of creosote, one of ingredients of Jungrowhan®, was the same of Jungrowhan®, and the others revealed no antifungal effect.


CONCLUSIONS: Even though Jungrowhan® and vinegar showed antifungal activity, using mixture of two material revealed no synergism. Their antifungal activity does not come from its herbal ingredients but just from creosote which is a kind of phenol mixture used for antiseptics, and acid of vinegar.



Keywords


Antifungal activity Creosote Jungrowhan® Vinegar




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