Abstract

Chromoblastomycosis is a chronic subcutaneous mycotic infections caused by dermatiaceous fungi. Clinically, chromoblastomycosis presents frequently with erythematous or nodular plaque. In Korea, 10 cases of chromoblastomycosis have been reported and Fonsecaea pedrosoi is the most common agent. A 61-year-old woman who was diagnosed as chronic inflammatory demyelinating polyneuropathy 3 years ago, and had been treated with systemic corticosteroids and azathioprine, presented with pruritic, scaly erythematous plaques on the right forearm for 3 years. She had no history of trauma. Histological examination showed pseudoepitheliomatous hyperplasia, mixed granulomatous inflammatory cell infiltrate and multinucleated giant cells with sclerotic cells in the dermis. Tissue culture showed slowly growing, dark brown, velvety colony. DNA was extracted from the cultured colonies and the DNA

sequence of the internal transcribed spacer (ITS) region of the clinical sample was matched for that of Fonsecaea monophora. The patient was treated with local heat therapy and topical terbinafine application.

Keywords

Chromoblastomycosis Fonsecaea monophora

KJMM 2014 March;19(1):18-24(7). Epub 2016 February 17
Copyright © 2014 by Korean Journal of Medical Mycology

Language

Korean/English

Author

Byeong Su Kim; Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea
Jin Hwa Choi; Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea
Seung Hyun Sohng; Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea
Dong Hoon Shin; Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea
Jong Soo Choi; Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea
Moo Kyu Suh; Department of Dermatology, College of Medicine, Dongguk University, Gyeongju, Korea

Corresponding

Jong Soo Choi, Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea. Tel: +82-53-620-3160, Fax: +82-53-622-2216, e-mail: jschoi@med.yu.ac.kr

Publication history

Received 2 January 2014; Revised 3 January 2014; Accepted 6 March 2014.

Acknowledgements

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Byeong Su Kim

Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea

Jin Hwa Choi

Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea

Seung Hyun Sohng

Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea

Dong Hoon Shin

Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea

Jong Soo Choi

Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea

Moo Kyu Suh

Department of Dermatology, College of Medicine, Dongguk University, Gyeongju, Korea

Since epub date 2016 February 17