Abstract

Background: Treatment of toenail onychomycosis requires long term oral medication of antifungal agent and its compliance was about 30% in outpatient base.

Objective: The objective of this study was to evaluate the efficacy and compliance of combined treatment with systemic and topical antifungal agent in toenail onychomycosis.

Method: Medical records of 402 patients with toenail onychomycosis were analysed. They were diagnosed by positivity in KOH or fungus culture. Two hundred forty patients took systemic antifungal agent (terbinafine or itraconazole) only (oral treatment group). One hundred sixty two patients took combined treatment with systemic antifungal agent and topical antifungal agent (ciclopirox 8% nail lacquer) (combined treatment group). Compliance, complete cure rate, revisiting rate and follow up period were compared between oral treatment group and combined treatment group.

Results: Completely treated rate was higher in combined treatment group (48.2%, 78 out of 162) than in oral treatment group (20.8%, 50 out of 240) (p=0.000, χ2). Complete cure rate after complete treatment was higher in combined treatment group (34.6%, 43 out of 78) than in oral treatment group (22.0%, 11 out of 50) (p=0.127, χ2). Revisiting rate after complete treatment was higher in combined treatment group (60.5%, 43 out of 71) than in oral treatment group (22.2%, 10 out of 45) (p=0.000, χ2).

Conclusion: All these findings suggested that combined treatment with systemic and topical agent in toenail onychomycosis can increase compliance and cure rate.

Keywords

Toenail onychomycosis Oral treatment Combined treatment

KJMM 2002 March;7(1):35-41(7). Epub 2016 February 22
Copyright © 2002 by Korean Journal of Medical Mycology

Language

Korean/English

Author

Hyun Chull Kim; Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea
Ki Baek Jung; Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea
Dong Hoon Shin; Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea
Jong Soo Choi; Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea
Ki Hong Kim; Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea

Corresponding

Ki Hong Kim, Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea. Tel: (053) 620-3160, Fax: (053) 622-2216, e-mail: khkim@med.yu.ac.kr

Publication history

Acknowledgements

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Hyun Chull Kim

Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea

Ki Baek Jung

Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea

Dong Hoon Shin

Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea

Jong Soo Choi

Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea

Ki Hong Kim

Department of Dermatology, College of Medicine, Yeungnam University, Taegu, Korea

Since epub date 2016 February 22