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Study of Empirical Antifungal Therapy in Febrile Neutropenia and Invasive Fungal Infection after Introduction of Novel Antifungal Agents

Eun Jung Lee,Tae Hyong Kim,Eun Ju Choo,Min Hyok Jeon
Epub 2016 February 18

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Abstract



Background: Patients with prolonged empirical broad spectrum antibiotics for febrile neutropenia (FN) with cancer, inevitably have increased risk of invasive fungal infections owing to the altered endogenous microbial environment.


Objective: The purpose of this study is to evaluate the impact of empirical antifungal therapy on occurrence of invasive fungal infections (IFIs) during FN with cancer.


Methods: We retrospectively reviewed medical records of patients with FN after cytotoxic chemotherapy due to cancer from July, 2003 to June, 2007.


Results: We identified 91 patients with FN after cytotoxic chemotherapy. Most common underlying conditions were lymphoma (20/91, 22%) and leukemia (20/91, 22%). IFIs occurred in 10% (9/91). In a comparison of patients with empirical antifungal therapy with no antifungal therapy, the duration of neutropenia was significantly increased with

IFIs (p=0.09). The mortality of IFIs was 55.5% (5/9).


Conclusion: We found that the duration of FN than empirical antifungal therapy affected occurrence of IFIs.



Keywords


Empirical antifungal therapy Febrile neutropenia




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