Abstract

Background: Candida albicans is a member of the normal flora of the skin, mucous membrane and gastrointestinal tract. Vaginal candidiasis remains a significant problem in women in childbearing age, Majority of the cases are caused by C. albicans and recurrence is common in spite of topical treatment.

Objective: The purpose of this study is to develop the antifungal agent from the medicinal herbs traditionally used in Korea.

Method: In this study, the extracts and essential oils from Foeniculum vulgare and Illicium verum were examined for antifungal activities against C. albicans.

Result: Dichloromethane extracts and essential oils from Foeniculum vulgare and Illicium verum showed antifungal activity against C. albicans. One fraction from Illicium verum with antifungal activity was founf out as 1-methoxy-4-(2-prophenyl) benzene.

Conclusion: Dichloromethane extract and 1-methoxy-4-(2-prophenyl) benzene with antifungal activity from Illicium verum could be the candidate for a new antifungal agent for candidiasis and other fungal diseases.

Keywords

Illicium verum Extract Antifungal activity Candida albicans

KJMM 2010 December;15(4):157-164(8). Epub 2016 February 18
Copyright © 2010 by Korean Journal of Medical Mycology

Language

Korean/English

Author

Sung Ho Park; Department of Microbiology, College of Medicine, Korea University
Inwha Seong; Department of Microbiology, College of Medicine, Korea University

Corresponding

Inwha Seong, Department of Microbiology, College of Medicine, Korea University. Tel: (02) 920-6167, Fax: (02) 923-3645, e-mail: inwha@korea.ac.kr

Publication history

Received 4 October 2010; Revised 3 January 2011; Accepted 4 January 2011.

Acknowledgements

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Sung Ho Park

Department of Microbiology, College of Medicine, Korea University

Inwha Seong

Department of Microbiology, College of Medicine, Korea University

Since epub date 2016 February 18